"Mine" chronicles Kelly Clarkson's post-divorce anxieties, sadness, and reflections. The singer has been open about the fact that the album tells the story of her split from Brandon Blackstock. "The whole divorce thing happened and I needed to write it," she told Variety in September 2022. "And then I didn't know if I was going to release it." After careful consideration, waiting a few years until she was ready, and communicating with Blackstock about the music, Clarkson released "Chemistry" on June 23, 2023. 

At the beginning of their relationship, Clarkson truly thought Blackstock was the one for her, as she recalls in the first verse of "Mine." "Thought with you maybe my heart wasn't meant to break," she sings. (The talk show host previously sang about all the hope she had for their romance in her emotional 2015 ballad, "Piece By Piece.") Later on in the track, she wishes for Blackstock to get a taste of his own medicine in his next relationship. "Right when you think it's perfect, they cross a line / And steal your shine like you did mine," Clarkson manifests. She also reveals in the "Mine" lyrics how she felt in the aftermath of the divorce — hopeless about love, unsure of herself, and no longer able to dream.