When "Billy on the Street" was picked up for television, Billy Eichner had to throw a crew together — fast. Eichner explained to Vanity Fair that one of the first people he hired for his writing team was Julie Klausner, as they were both fans of each other's work. After working on Eichner's show, Klausner created "Difficult People" for her and Eichner to star in.

Amy Poehler eventually joined the project as an executive producer, and it aired on Hulu in 2015 for three seasons. EW recounts the show's wonderful comedic guest stars through its three seasons, including John Cho, Kate McKinnon, Fred Armisen, Seth Meyers, Lin-Manuel Miranda, John Mulaney, Tina Fey, and Amy Poehler. The show follows two aspiring comedians, Julie Kessler and Billy Epstein, who seek success in New York's entertainment industry. They are exaggerated, dumber versions of Klausner and Eichner themselves. According to Deadline, the show's pilot was made for USA, but Eichner and Klausner are both happy it aired on Hulu because of the show's content: "It's impossible to think of this show on USA," Eichner said.

When the show was canceled in 2017, Eichner tweeted, "Yes it's true. 'DIFFICULT PEOPLE' has come to an end. Thanks to many people but above all my friend, [Julie Klausner]. A singular comedic voice & the funniest person I know. I cannot WAIT to see what Julie creates next." Though "Difficult People" was cancelled, it remains beloved by its many dedicated fans.