Given the fact that Adam and Danielle Busby seem to enjoy being parents so much, one might assume that they are open to having more children in the future. In a 2019 YouTube video, Danielle revealed that she had developed Polycystic Ovary Syndrome, and, as a result, had to get a hysterectomy. Due to the fact that Danielle had to get a hysterectomy, the couple will no longer be able to have their own biological children. However, as Danielle told Entertainment Tonight, the Busbys are not too upset about this inability to have any more children.

Danielle confirmed, "There's no more, but if we ever want a little boy around, we just go grab those two little nephews of ours, then we have them for a day, and we're like, 'That's enough.'" Despite the fact that they can't have their own biological children, Danielle and Adam are still open to adoption. "We'd never fully closed the door on an adoption," Adam said. "If, like, something came our way and pressed on our heart, that we needed to help, we never closed the door on that. But as far as having kids of our own, it's pretty much impossible at this point."