After their father is called into work, two young boys, Walter and Danny, are left in the care of their teenage sister, Lisa, and told they must stay inside. Walter and Danny, who anticipate a boring day, are shocked when they begin playing Zathura, a space-themed board game, which they realize has mystical powers when their house is shot into space. With the help of an astronaut, the boys attempt to return home.

Cal Weaver is living the American dream. He has a good job, a beautiful house, great children and a beautiful wife, named Emily. Cal's seemingly perfect life unravels, however, when he learns that Emily has been unfaithful and wants a divorce. Over 40 and suddenly single, Cal is adrift in the fickle world of dating. Enter, Jacob Palmer, a self-styled player who takes Cal under his wing and teaches him how to be a hit with the ladies.

Disconnect interweaves multiple storylines about people searching for human connection in today’s wired world. Through poignant turns that are both harrowing and touching, the stories intersect with surprising twists that expose a shocking reality into our daily use of technology that mediates and defines our relationships and ultimately our lives.