A myriad of conditions can cause different types of acne; for the most part, they're all typically linked to excess sebum and dead skin cells that mingle together underneath the surface of the skin. While they're irritating, painful, and often itchy, they don't come from the same sources as blisters, mosquito bites, or other things that calamine lotion is used for.

There are acne products that contain calamine lotion — the Mario Badescu Drying Lotion is a popular one. However, it's formulated with other acne-fighting ingredients that also help out. Calamine lotion can certainly soothe the skin, but it's not a preventative measure. You'll find temporary relief, but without getting to the source, you'll still get breakouts again.

As an anti-inflammatory, calamine lotion can be used to alleviate those red, inflamed breakouts, but it won't do much beyond that. To apply it, you'll need to clean the area beforehand. Using a clean Q-tip, dot on the calamine lotion and let it dry. Unless you have sensitive skin, you can leave it on overnight.