It turns out the actress was not the only person who struggled with the huge shakeup of the Grey's Anatomy cast — come on, we were still getting over saying goodbye to Izzie Stevens and George O'Malley! 

As Rhimes said in a statement per USA Today in 2013, "Over the past 10 seasons, I have been made better by Sandra's trust, faith and friendship and I can't quantify how grateful I am for her collaboration on a character we both love so deeply. This year is going to be bittersweet for us – we're both going to savor every moment of Cristina Yang and then we're going to give her the exit she deserves. And when Sandra walks out of my door, Grey's Anatomy will once again be forever changed."

Meanwhile, according to Cheat Sheet, Ellen Pompeo, who of course still plays Meredith Grey, said about Oh leaving, "She was such an amazing scene partner. Then I was like, 'Is there a show without Sandra?'"

Well, there is a show, but many fans would argue it was never the same once Oh left Grey Sloane. And don't even get us started on Dr. Derek Shepherd's departure!