Having come to comedy in a very nontraditional manner, it shouldn't be surprising that the topics addressed by Elyse Myers are also far from typical. For Myers, it's all about maintaining a warts-and-all openness with fans, which includes sharing her own issues with anxiety, depression, and ADHD, all while trying to quell that internal voice in her head telling her she's not good enough — that if she attempts anything outside of her comfort zone, she's destined for failure. "I just don't understand why our brains actively try to fight against us in that way," told Vanity Fair.

In fact, it's that openness about herself that has led so many to connect with her, with Myers addressing the same issues many of her fans are dealing with. "I've had really high highs, and really low lows," she told People, explaining why she feels it's important to have these discussions in an open, honest, and often funny way. "It's important to me to make it a really normal thing," she added, "to be able to be at coffee with somebody and be like, 'Yeah and then I was super depressed for a while.' To have that not be awkward is really important to me."

In a particularly resonant TikTok video, she offered some surprisingly simple advice on coping with anxiety and fear. "Someone asked me how I manage my nerves, and I said, 'I don't. I don't. I just do things scared.'"